Abstract: Habituation is a type of learning that consists of a decrease in the response to a repetitive stimulus. The traditional view is that habituation comprises two processes: a transitory one called short-term habituation (STH), promoted by stimulus presentations at short intervals, and a more durable one called long-term habituation (LTH), promoted by more spaced repetitions. Due to the importance of time in this distinction and in an attempt to elucidate its underlying mechanisms, several studies have sought to relate habituation to brain activity through the analysis of event-related potentials (ERPs). We performed a systematic review of studies on habituation of ERPs in humans using the PRISMA methodology. A total of 175 articles were evaluated for eligibility and 145 were included. Most of the studies focused on short-term effects, demonstrating habituation in a range of ERP components such as P50, P1, N1, P2, N2, and P3. These studies revealed that STH occurs with intervals ranging from 75 ms to 4 s with an optimal of 500 ms, but it does not with intervals greater than 10 s. There are also some studies showing that the P1, N1, P2, N2, and P3 components exhibit LTH with inter-stimulus intervals between 3 and 10 seconds, but the evidence is yet insufficient to establish a secure conclusion with respect to LTH. We propose that future studies should use a wider range of inter-stimulus intervals with tests of both short-and long-term habituation so that the specific neurophysiological components of each type of habituation could be determined.

Resumen: La habituación es un tipo de aprendizaje que consiste en una disminución en la respuesta a un estímulo repetitivo. La visión tradicional es que la habituación comprende dos procesos: uno transitorio llamado Habituación de Corto Plazo (HCP), promovido por presentaciones de estímulos a intervalos cortos, y uno más duradero llamado Habituación de Largo plazo (HLP), promovido por repeticiones más espaciadas. Debido a la importancia del tiempo en esta distinción y en un intento por elucidar sus mecanismos subyacentes, varios estudios han buscado relacionar la habituación con la actividad cerebral a través de los potenciales relacionados a eventos (PRE). Realizamos una revisión sistemática acerca de la habituación de PREs en humanos utilizando la metodología PRISMA. Evaluamos la elegibilidad de 175 artículos y se incluyeron 145. La mayoría de los estudios se centran en los efectos a corto plazo, donde se demostró habituación en componentes tales como P50, P1, N1, P2, N2, P3. Estos estudios revelan que la HCP ocurre con intervalos entre 75 ms y 4 s, con un óptimo de 500 ms, pero no con intervalos mayores a 10 segundos. Otros estudios han demostrado que los componentes P1, N1, P2, N2 y P3 exhiben HLP con intervalos entre estímulos de 3 a 10 segundos, pero la evidencia aún es insuficiente para establecer una conclusión segura. Proponemos que los estudios futuros deberían utilizar una gama más amplia de intervalos, con pruebas tanto de habituación de corto como de largo plazo, de modo que se puedan determinar los componentes neurofisiológicos específicos de cada tipo de habituación.

RESUMO Introdução: a recorrência da hérnia inguinal após hernioplastia varia de 0,5 a 15 por cento, dependendo do local da hérnia, tipo de reparo e circunstâncias clínicas. Muitos fatores de risco são conhecidos e devem ser considerados antes do procedimento. Acompanhamento e adequado bancos de dados são fundamentais para entender a incidência de recidiva. Métodos: estudo de coorte retrospectivo analisou hernioplastias inguinais realizados no Hospital de Clínicas de Porto Alegre entre 2013 e 2015. Para concluir 5 anos de seguimento, analisamos o prontuário e fizemos contato telefônico e por correio. Resultados: o total de 1094 registros médicos foram selecionados e um seguimento de pelo menos 5 anos foi possível em 454 pacientes - 538 reparos de hérnia inguinal devido à abordagem bilateral em 84 pacientes. Os pacientes responderam um questionário validado sobre sintomas de recorrência. A taxa total de recorrência foi de 9,29%. No grupo masculino, a recorrência foi de 10% contra 4% no grupo feminino. Para os pacientes com hérnia Nyhus IV, a recidiva foi de 24% contra 8% após o reparo da hérnia primária, com um risco de 2,8 maior. Não houve diferença na recorrência entre cirurgiões experientes e em treinamento. Conclusão: nossos dados revelam uma taxa de recorrência aceitável em um hospital de ensino, e para o nosso conhecimento é o primeiro artigo com acompanhamento de longo prazo no sul do Brasil. A re-recidiva da hérnia foi maior quando comparada com o reparo da hérnia primária.

ABSTRACT Introduction: recurrence rates for primary hernia repair range from 0.5 to 15 percent depending upon the hernia site, type of repair, and clinical circumstances. Many risk factors are known and they must be considered before the procedure. In developing countries, follow up and maintenance of databases are critical to understand the real numbers. Methods: a retrospective cohort study analyzed adult patients who have undergone inguinal hernia repair at Hospital de Clínicas de Porto Alegre, a tertiary care government public hospital, between 2013 and 2015. Medical records, telephone, and letter contact have been reviewed in order to complete the minimum period of 5 years of follow-up. The analyzed data focused on the surgeon’s experience and the recurrence rate in 5 years of follow-up. Results: a total of 1094 medical records were selected and a complete five years follow-up were possible in 454 patients - 538 inguinal hernia repairs due to bilateral approach in 84 patients. These 454 patients answered, in a validated questionnaire about symptoms of recurrence. The total recurrence rate was 9.29%. For the patients who had Nyhus IV, recurrence rate was 24.1% against 9.9% after primary hernia repair, with a 2.4 higher risk. There was no difference in recurrence between surgeons and training surgeons. Conclusion: our data reveal an acceptable recurrence rate in a tertiary care hospital with residents, and to our knowledge is the first Brazilian report with long term follow up. An increased re-recurrent hernia was found when compared with primary hernia repair.

Resumen En un experimento de sobresalto potenciado por el miedo, los participantes fueron entrenados en una tarea de discriminación donde una imagen A se emparejó con un pulso eléctrico, mientras que otra imagen, B, se presentó por sí sola (i.e., A+ B-). En una prueba, la respuesta de sobresalto, medida como parpadeo, fue evaluada al presentar un soplo de aire o un ruido blanco en presencia o ausencia de las imágenes A y B. Los resultados muestran un mayor parpadeo al soplo de aire en presencia de A que en presencia de B, y en ausencia de cualquier estímulo, solo en aquellos participantes que percibieron el pulso eléctrico como altamente doloroso. En conclusión, estos hallazgos sugieren que el miedo condicionado se relaciona linealmente con la intensidad del pulso eléctrico.

Abstract In a fear-potentiated startle experiment, participants were trained in a discrimination task where image A was paired with an electrical pulse, while another image, B, presented itself (i.e., A+ B-). In a test, the startle response, measured as an eyeblink, was evaluated by presenting an air-puff or white noise in the presence or absence of images A and B. The results show a greater eyeblink to the air-puff in the presence of A than in the presence of B, and in the absence of any stimulus, only in those participants who perceived the electrical pulse as highly painful. In conclusion, these findings suggest that conditioned fear is linearly related to the intensity of the electrical pulse.

SUMMARY OBJECTIVE: The sudden COVID-19 outbreak has changed our health system. Physicians had to face the challenge of treating a large number of critically ill patients with a new disease and also maintain the essential healthcare services functioning properly. To prevent disease dissemination, authorities instructed people to stay at home and seek medical care only if they experienced respiratory distress. However, there are concerns those patients did not seek necessary health care because of these orientations. This study aims to see how the pandemic has influenced the severity of the disease, complication, and mortality of patients undergoing emergency cholecystectomy and appendectomy. METHODS: Retrospective review of medical records of patients admitted to the emergency department and undergoing to cholecystectomy and appendicectomy in the periods from March to May 2019 and 2020. RESULTS: We observed that COVID-19 did not change the severity of presentation or the outcome of patients with gallbladder disease, but caused a 24.2% increase in the prevalence of complicated appendicitis (p<0.05). However, disagreeing with what was expected, we did not identify a greater number of perioperative complications in patients undergoing an appendectomy. CONCLUSION: Therefore, it seems that in a university tertiary referral center COVID-19 did not influence the management and outcome of inflammatory diseases treated in the surgical emergency department.

Resumo Este artigo analisa como a questão da cidadania e possíveis aspectos relacionados a esse tema (a construção de identidades, a diversidade, o direito à memória, a aprendizagem significativa, as práticas avaliativas inclusivas etc.) repercutem nos princípios norteadores, nos fundamentos para o ensino de História, na metodologia de ensino e aprendizagem, no estabelecimento das competências e habilidades esperadas em cada etapa da vida escolar e na organização dos conteúdos na grade curricular presentes no Currículo do Estado de São Paulo: Ciências Humanas e suas tecnologias para o ensino dessa disciplina na educação básica. Trata-se de uma repercussão relevante no programa curricular devido à sua influência no cotidiano das atividades didáticas desenvolvidas em sala de aula e à importância da disciplina para a constituição da identidade do discente e a sua formação enquanto cidadão atuante e agente transformador da realidade, na medida em que aborda os acontecimentos históricos como resultado das ações de todos os homens e não apenas de “grandes personagens” (governantes, diplomatas, generais etc.), e os direitos políticos, sociais e civis como produto de demandas, negociações, lutas e conquistas de diversos grupos e movimentos sociais ao longo do tempo.

Abstract This article analyzes how the issue of citizenship and possible aspects related to this theme (the construction of identities, diversity, the right to memory, meaningful learning, inclusive evaluative practices, etc.) have repercussions on guiding principles, teaching of History, teaching and learning methodology, establishing the skills and abilities expected at each stage of school life and the organization of the contents in the curriculum grid present in the State of São Paulo Curriculum: Human Sciences and its technologies for teaching this discipline in basic education. This is a relevant repercussion in the curricular program due to its influence in the daily activities of the didactic activities developed in the classroom and to the importance of the discipline for the constitution of the identity of the student and their formation as an active citizen and transforming agent of reality in the measure which addresses historical events as a result of the actions of all men and not just "big characters" (rulers, diplomats, generals, etc.) and political, social and civil rights as a product of demands, negotiations, struggles and conquests of groups and social movements over time.

Abstract The redundancy effect is the finding of greater learning when an X stimulus is trained in an A+ AX+ blocking procedure, than when a Y stimulus is trained in a BY+ CY- discrimination procedure. These findings are new and theoretically challenging for all conditioning theories that calculate learning based on a common error. For this reason, we alternatively examined the possibility that the phenomenon is the result of a propositional reasoning. In an experiment, we replicated the basic effect and we found out that the addition of instructions on the occurrence of the consequences at a submaximal level does not have a significant impact on the redundancy effect. These findings are discussed with regard to a propositional and associative approach based on the assumption that the experimental stimuli share a common feature.

Resumen El efecto de redundancia es el hallazgo de un mayor aprendizaje a un estímulo X entrenado en un procedimiento de bloqueo A+ AX+, que a un estímulo Y entrenado en un procedimiento de discriminación BY+ CY-. Estos hallazgos son nuevos y teóricamente desafiantes para todas las teorías del condicionamiento que calculan el aprendizaje en base a un error común. Es por ello que examinamos alternativamente la posibilidad que el fenómeno sea el resultado de un razonamiento proposicional. En un experimento, replicamos el efecto básico y encontramos que la adición de instrucciones sobre la ocurrencia de las consecuencias a un nivel sub-máximo no tiene un efecto significativo sobre el efecto de redundancia. Estos hallazgos son discutidos en relación con una aproximación proposicional y asociativa basada en el supuesto que los estímulos experimentales comparten un elemento común.

Abstract The study examines the effects of context change on the habituation of the startle response in humans. In Experiment 1 the startle response was measured in three phases: pre-test, habituation, and post-test. For one group, the phases occurred in the same context, while for another, the habituation phase occurred in a different context. The results indicated that the different group had a more marked decrease between the pre-test and post-test than the same group. In Experiment 2, the same design was replicated, and the same results were obtained as in Experiment 1, although a different stimulus was used in the pre-test and post-test. Although the results are not statistically conclusive, they suggest that the context could be acquiring long-term potentiating properties that reduce the level of decrement that would be observed if only a habituation process existed.

Resumen El estudio examina los efectos del cambio de contexto en la habituación de la respuesta de sobresalto en humanos. En el Experimento 1 se midió la respuesta de sobresalto en tres fases: preprueba, habituación y posprueba. Para un grupo, las fases ocurrieron en el mismo contexto, mientras que para otro, la fase de habituación ocurrió en un contexto distinto. Los resultados indicaron que el grupo diferente tuvo una disminución más marcada entre la preprueba y la posprueba que el grupo igual. En el Experimento 2, se replicó el mismo diseño y se obtuvieron los mismos resultados que en el Experimento 1, pese a que en la preprueba y la posprueba se utilizó un estímulo distinto. Aunque los resultados no son estadísticamente concluyentes, estos sugieren que el contexto podría estar adquiriendo propiedades potenciadoras de largo plazo que reducen el nivel de decremento que se observaría si sólo existiera un proceso de habituación.

É descrito o caso de um adolescente masculino de 14 anos de idade com antecedentes de dor abdominal recorrente e dois episódios “sub- oclusivos” prévios. Recorreu às urgências com dor abdominal e vómitos. Ao exame objetivo, era evidente distensão abdominal e sinais de irritação peritoneal. A radiografia abdominal simples de pé sugeriu a presença de obstrução do íleo distal. Foi realizada uma laparoscopia exploratória, que evidenciou uma estrutura tubular a ligar o bordo antimesentérico do íleo terminal ao umbigo e se comportava como eixo de rotação. Foi efetuada de-rotação do vólvulo e excisão da estrutura. O exame histológico confirmou o diagnóstico de ducto onfalomesentérico persistente. O presente caso ilustra uma obstrução intestinal causada por vólvulo do íleo distal, sendo necessário um alto índice de suspeição para reconhecer esta etiologia.

This report describes the case of a 14-year-old male with a prior history of recurrent abdominal pain and two previous ”sub-occlusive” episodes. He presented at the Emergency Room with abdominal pain, emesis, abdominal distension, painful palpation, and signs of peritoneal irritation. Plain upright abdominal radiography suggested a distal small bowel obstruction. Exploratory laparoscopy showed a tubular structure connecting the antimesenteric border of the terminal ileum and the umbilicus, which was behaving as a rotation axis to the small intestine. The volvulus was laparoscopically de-rotated, and the structure was excised. Histological exam confirmed the diagnosis of persistent omphalomesenteric duct. This case illustrates an intestinal obstruction caused by small intestine volvulus. A high index of suspicion is required to acknowledge this etiology.

Abstract The treatment of patients with relapsed and/or refractory multiple myeloma has improved considerably in the last 15 years, after the introduction of proteasome inhibitors and immunomodulatory drugs. The first clinical trials with new proteasome inhibitors have produced exciting results, particularly those comparing triplet regimens with standard doublet regimens, with a gain in progression-free survival accompanied by an acceptable safety profile and either similar or better health-related quality of life. New proteasome inhibitors hold the potential to fill unmet needs in multiple myeloma management regarding improvement of clinical outcomes, including delayed progression of disease in high-risk patients. This review summarizes the main pharmacological properties and clinical outcomes of these agents, and discusses their potential to change the whole multiple myeloma therapeutic landscape.

ABSTRACT Mycobacterium haemophilum is a nontuberculous mycobacterium that causes localized or disseminated disease, mainly in immunocompromised hosts. We report the case of a 35-year-old HIV-infected woman who presented with several enlarging cutaneous lesions over the arms and legs. Histopathological examination revealed the diagnosis of a cutaneous mycobacterial disease. Mycobacterial analyses unveiled M. haemophilum infection. Six months after completion of a successful antimycobacterial treatment, she developed an immune reconstitution inflammatory syndrome (IRIS). This paradoxical relapse presented as tenderness, redness and swelling at the precise sites of the healed lesions and took place in the setting of significant recovery of the CD4 cell count (from 05 to 318 cells/mm 3 ). Microbiological analyses of these worsening lesions were negative, and they spontaneously remitted without the initiation of a novel antimycobacterial treatment cycle. M. haemophilum infection should always be considered as a cause of skin lesions in immunocompromised subjects. Physicians should be aware of the possibility of IRIS as a complication of successful antiretroviral therapy in HIV-infected patients with M. haemophilum infection.

O ritmo e escala de crescimento do turismo urbano colocam novos desafios à compreensão dos processos contemporâneos de gentrificação, designadamente em cidades médias internacionalmente abertas e com um valor patrimonial muito importante. Baseados no caso do Porto (Portugal), exploramos dois destes desafios. Primeiro, defendemos que o conceito está a tornar-se baste difuso e que há uma necessidade evidente de considerar diferentes tipos de transformação urbana acelerada, nomeadamente social (de residentes) e/ou económica (relacionada com atividades). Em segundo lugar, defendemos uma melhor apreciação do contexto histórico, argumentando que os processos de gentrificação orientados pelo lazer acontecem há vários séculos no Porto. Em terceiro lugar, comparamos os processos de gentrificação promovidos pelos britânicos no século XXI na cidade com as transformações urbanas contemporâneas no centro da cidade, destacando a alteração funcional sem precedentes imposta pelos visitantes internacionais e pelos “utilizadores flutuantes da cidade”, bem como o número de desafios que se colocam à manutenção da diversidade, considerando as bases que deveriam sustentar o desenvolvimento local.

The speed and scale of urban tourism growth raises new challenges to understand contemporary gentrification processes, namely for internationally open, heritage-rich medium-sized cities. Based on the case of Porto (Portugal), we explore two of such challenges. First, we claim that the concept is becoming rather diffuse and that there’s a need to consider different types of rapid urban change, namely social (of residents) and/or economic (related with activities). Second, we defend a better appreciation of history by arguing that leisure-led gentrification processes have been taking place for centuries in Porto. Third we compare 19th century British-driven gentrification processes in the city with contemporary urban change in its central district, in order to highlight the unprecedented functional change imposed by international visitors and “floating city users”, as well as a number of associated challenges in keeping diversity having in mind what local development should be about.

A persistência do ducto onfalomesentérico pode ser responsável pela formação de um volvo intestinal na porção do intestino delgado, uma causa rara de abdómen agudo em crianças. Uma criança de quatro anos de idade foi admitida no Serviço de Urgência por dor abdominal e vómitos incoercíveis, sem defesa abdominal nem alterações significativas nos exames auxiliares de diagnóstico. Devido a um agravamento clínico significativo no período de 48 horas em que esteve sob observação, foi transferida para um hospital terciário, com acesso a cirurgia pediátrica. Uma nova avaliação ecográfica abdominal, que demonstrou extensa distensão abdominal e presença de líquido livre, levou a exploração cirúrgica, tendo sido identificado e removido um volumoso quisto do canal onfalomesentérico. Quando sintomática, a orientação terapêutica desta patologia é consensual, consistindo na excisão cirúrgica do defeito anatómico, que foi efetuada. Conclusão: A persistência do ducto do canal onfalomesentérico é uma condição rara, cujo diagnóstico exige um elevado nível de suspeição, sendo muitas vezes detetado apenas durante a cirurgia. A taxa de complicações e mortalidade é elevada e uma intervenção atempada é essencial, dado que a remoção cirúrgica constitui a única opção de tratamento.

A persistent omphalomesenteric duct is one possible cause of small-bowel volvulus, a rare cause of acute abdomen in children. A four-year-old child was admitted to the Emergency Department with abdominal pain and incoercible vomiting, with neither abdominal guarding nor relevant abnormalities revealed in complementary diagnostic exams. Due to a significant clinical deterioration over a 48-hour observation period, the child was transferred to a tertiary hospital with pediatric surgery. An abdominal ultrasound revealing severe bowel distension and increased abdominal free fluid warranted an exploratory surgery, which identified a voluminous omphalomesenteric duct cyst. When symptomatic, treatment of this condition is consensual and consists of surgical excision of the anatomical abnormality, either by laparoscopy or conventional surgery. The latter was performed. Conclusion: A persistent omphalomesenteric duct is a rare condition that generally requires a high level of clinical suspicion for diagnosis to be made, being most commonly detected during surgery. Associated complications and mortality rates are high, and a timely intervention is key, since surgical removal is the only treatment option.

Resumo Objetivo Rever as taxas de transmissão vertical (TV) do HIV-1 na área metropolitana de Belo Horizonte, Brasil, de janeiro de 2006 a dezembro de 2014. Métodos Estudo descritivo de uma coorte prospectiva de gestantes infectadas pelo HIV-1 e seus filhos, monitorados pelo Grupo de Pesquisa em HIV/Aids Materno-Infantil, da Faculdade de Medicina da Universidade Federal de Minas Gerais, Brasil. Resultados A taxa geral de TV foi de 1,9% (13/673; intervalo de confiança [IC] 95%: 1,0-3,3). O uso extensivo de terapia antirretroviral combinada (TARVc) (89,7%; 583/ 650) impactou fortemente a redução de TV durante este período. Carga viral materna superior a 1.000 cópias/mL mostrou associação significante com TV (OR: 6,6; IC 95%:1,3-33,3). A amamentação materna foi descrita em 10 casos nesta coorte (1,5%; IC 95%: 0,7-2,7), mas não foi associada à TV. Conclusão Os dados atuais da coorte foram coerentes com a baixa taxa de TV descrita em outras populações globais, e foi consideravelmentemenor em comparação com os resultados da mesma coorte no período de 1998-2005, quando a taxa de TV foi de 6,2%. Esses dados confirmam a eficiência das Diretrizes Nacionais, e enfatizam a importância de adotar os procedimentos internacionais recomendados para a prevenção da transmissão do HIV da mãe para o filho.

Abstract Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014. Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil. Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0-3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3-33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7-2.7), but it was not associated with VT. Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998-2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-tochild transmission (MTCT) of HIV.

ABSTRACT Objectives The increase in HIV transmissibility in non-ulcerative sexually transmitted infection is already well-established. It is estimated that symptomatic carriers of N. gonorrhoeae and C. trachomatis have a relative risk of 4.8-fold and 3.6-fold, respectively, for the sexual acquisition of HIV. This type of evaluation for asymptomatic urethritis is necessary to reinforce strategies to combat HIV transmission. This study aims to assess the prevalence of patients with asymptomatic urethritis among men diagnosed with HIV-1 and determine the risk factors associated with this infection. Methods We enrolled a total of 115 male patients aged 18 years or older who have been diagnosed with HIV infection and have no symptoms of urethritis or other sexually transmitted infections and who have been evaluated between May and August 2015 in a follow-up visit at the Immunology Outpatient Clinic of a Brazilian University Hospital. Results Four asymptomatic patients were positive for C. trachomatis and were considered asymptomatic carriers of urethritis. Prevalence was 3.47%. Patients who were positive for C. trachomatis urethritis had a lower mean age (p = 0.015). Conclusion The presence of asymptomatic sexually transmitted infection is a challenge in clinical practice. We recommend that, in outpatient practice, the habit of inquiring on previous sexual behavior to obtain more information about risks and associations with asymptomatic sexually transmitted infection, a routine physical examination and complementary tests to detect STI pathogens should be performed to discard these conditions. The development of rapid tests for this purpose should also be encouraged.

ABSTRACT Although Pityriasis Rosea is considered a benign cutaneous condition, in the context of pregnancy, there are studies that relate the appearance of this pathology with associated complications in the fetus. Methodology: A prospective case report was made to a 36-year-old Chilean woman who presented this pathology during the twelve weeks of pregnancy. The objective was to describe, the evolution and control and to contrast its evolution with the current scientific evidence on this subject. Results: Patient presents concordant erythematous-desquamative plaques with diagnosis of Pityriasis Rosea (surface affected less than 50% of his body), without presenting enanthem, nor systemic symptoms. Had a healthy newborn at 38 weeks of gestation, without presenting any adverse effect related to the analyzed literature. Conclusions: Different studies have studied the possible adverse effects on the fetus in mothers who have presented pityriasis rosea in pregnancy, however in this case report there were no associated complications. Missing studies in a greater number of patients.

RESUMEN A pesar de que la Pitiriasis Rosada se considera una condición cutánea benigna, en el marco del embarazo, hay estudios que relacionan la aparición de esta patología con complicaciones asociadas en el feto. Metodología: Se realiza un reporte de caso, prospectivo, a una mujer de 36 años chilena que presentó esta patología durante la semana 12 de gestación. El objetivo fue describir, la evolución y control y contrastar su evolución con la evidencia científica actual sobre esta temática. Resultados: Paciente presenta placas eritematodescamativas concordantes con diagnóstico de pitiriasis rosada (superficie afectada menos al 50% de su cuerpo), sin presentar enantema, ni síntomas sistémicos. Tuvo un recién nacido sano a las 38 semanas de gestación, sin presentar ningún efecto adverso de los que relaciona la literatura analizada. Conclusiones: Distintos estudios han estudiado los posibles efectos adversos en el feto en madres que han presentado Pitiriasis Rosada en el embarazo, sin embargo, en este reporte de caso no se presentaron complicaciones asociadas. Faltan estudios realizados en mayor cantidad de pacientes.